Cholecyctokinin And Panic Disorder

Cholecyctokinin and panic ail Cholecyctokinin is a neuropeptide found in the GI system and brain. Research has shown that it has various isolated severs that may moderate several important aras of human behavior, such as nociception, surfeit and anxiety. Cholecystokinin receptors located in the central nervous system (CNS) atomic number 18 known as CCK-B receptors, and they have high affinity for the tetrapeptide fraction CCK-4.

Anxiogenic effect of CKK-4 in humans suggested that it might be involved in pathogenesis of panic pain, and opened new avenues of research into biologic aspects of anxiety. Further research showed increased sensitivity of panic disorder patients to CCK-4 in comparison with normal volunteers. Next, substances capable of blocking CCK-B receptors (CCK-B antagonists) were synthesized and their action mechanism was evaluated. One of such antagonists, L-365,260 proved to be effective in blocking CCK-4 induced panic attacks in panic disord...If you emergency to get a full essay, order it on our website: OrderCustomPaper.com

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